Transient state model of actin-based motility
نویسندگان
چکیده
منابع مشابه
Mechanism of actin-based motility.
Spatially controlled polymerization of actin is at the origin of cell motility and is responsible for the formation of cellular protrusions like lamellipodia. The pathogens Listeria monocytogenes and Shigella flexneri, which undergo actin-based propulsion, are acknowledged models of the leading edge of lamellipodia. Actin-based motility of the bacteria or of functionalized microspheres can be r...
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they move. Deadhesion/tail retraction may limit moveIntroduction ment rate in such cells. In weakly adhesive, fast moving Most animal cell types possess the capacity to move cells such as amoebae and white blood cells, the tail is over or through a substrate, and cell locomotion plays more rounded and this step is more efficient. Adhesion a key role in bothnormal physiology and disease.Certain ...
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Actin polymerization provides a major driving force for eukaryotic cell motility. Successive intercalation of monomeric actin subunits between the plasma membrane and the filamentous actin network results in protrusions of the membrane enabling the cell to move or to change shape. One of the challenges in understanding eukaryotic cell motility is to dissect the elementary biochemical and biophy...
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We present a simple and generic theoretical description of actinbased motility, where polymerization of filaments maintains propulsion. The dynamics is driven by polymerization kinetics at the filaments’ free ends, crosslinking of the actin network, attachment and detachment of filaments to the obstacle interface and entropic forces. We show that spontaneous oscillations in the velocity emerge ...
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The function of vasodilator-stimulated phosphoprotein (VASP) in motility is analyzed using a biomimetic motility assay in which ActA-coated microspheres propel themselves in a medium containing actin, the Arp2/3 complex, and three regulatory proteins in the absence or presence of VASP. Propulsion is linked to cycles of filament barbed end attachment-branching-detachment-growth in which the ActA...
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ژورنال
عنوان ژورنال: Theoretical and Applied Mechanics Letters
سال: 2011
ISSN: 2095-0349
DOI: 10.1063/2.1101402